pI: 7.0011 |
Length (AA): 189 |
MW (Da): 21129 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
8 | 179 | 1vaj (A) | 13 | 195 | 27.00 | 0 | 1 | 1.23685 | -0.51 |
9 | 178 | 1zq7 (A) | 11 | 188 | 28.00 | 0 | 1 | 1.25827 | -0.63 |
32 | 171 | 1wsc (A) | 50 | 198 | 34.00 | 0.0000000014 | 1 | 1.04264 | 0.38 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127328)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G38710 | AMMECR1 family protein |
Babesia bovis | BBOV_II003340 | conserved hypothetical protein |
Brugia malayi | Bm1_33695 | AMME syndrome candidate gene 1 protein homolog, putative |
Candida albicans | CaO19.2047 | similar to S. cerevisiae YOR289W |
Candida albicans | CaO19.9595 | similar to S. cerevisiae YOR289W |
Caenorhabditis elegans | CELE_R166.3 | Protein R166.3 |
Dictyostelium discoideum | DDB_G0283437 | AMMECR1 family protein |
Drosophila melanogaster | Dmel_CG5902 | CG5902 gene product from transcript CG5902-RA |
Echinococcus granulosus | EgrG_000066600 | AMME syndrome candidate gene 1 protein |
Entamoeba histolytica | EHI_067940 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_143570 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000066600 | AMME syndrome candidate gene 1 protein |
Giardia lamblia | GL50803_9349 | Hypothetical protein, similar to AMMECR1 |
Homo sapiens | ENSG00000144233 | AMMECR1-like |
Homo sapiens | ENSG00000101935 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 |
Leishmania braziliensis | LbrM.32.0710 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_320660.1 | AmmeMemoRadiSam system protein A/uncharacterized protein, PH0010 family, putative |
Leishmania infantum | LinJ.32.0660 | hypothetical protein, conserved |
Leishmania major | LmjF.32.0630 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.31.0630 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_09146 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06836 | hypothetical protein |
Mus musculus | 56068 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 |
Mus musculus | ENSMUSG00000041915 | AMME chromosomal region gene 1-like |
Neospora caninum | NCLIV_047300 | AMMECR1 family protein, related |
Neospora caninum | NCLIV_017320 | Similar to uniprot |
Oryza sativa | 4349471 | Os10g0573100 |
Onchocerca volvulus | OVOC2822 |
|
Plasmodium berghei | PBANKA_1348100 | conserved protein, unknown function |
Plasmodium falciparum | PF3D7_1333400 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_1267200 | conserved protein, unknown function |
Plasmodium vivax | PVX_082600 | hypothetical protein, conserved |
Plasmodium yoelii | PY02102 | Protein of unknown function, putative |
Saccharomyces cerevisiae | YOR289W | hypothetical protein |
Schistosoma japonicum | Sjp_0037400 | AMME syndrome candidate gene 1 protein, putative |
Schistosoma mansoni | Smp_075640.3 | ammecr1 homolog |
Schistosoma mansoni | Smp_075640.2 | ammecr1 homolog |
Schistosoma mansoni | Smp_075640.1 | ammecr1 homolog |
Schmidtea mediterranea | mk4.000265.03 | Putative ammecr1 homolog |
Schmidtea mediterranea | mk4.000089.00 | Putative ammecr1 homolog |
Schmidtea mediterranea | mk4.000265.04 | |
Trypanosoma brucei gambiense | Tbg972.11.15490 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.13870 | uncharacterized protein, PH0010 family/AmmeMemoRadiSam system protein A, putative |
Trypanosoma congolense | TcIL3000.11.14240 | uncharacterized protein, PH0010 family/AmmeMemoRadiSam system protein A, putative |
Trypanosoma cruzi | TcCLB.509161.60 | uncharacterized protein, PH0010 family/AmmeMemoRadiSam system protein A, putative |
Toxoplasma gondii | TGME49_225413 | hypothetical protein |
Toxoplasma gondii | TGME49_242000 | DUF51 family protein |
Theileria parva | TP04_0257 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_130770 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_326010 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.5440 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5440 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5440 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.5440 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1348100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_242000 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_225413 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.